Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lysosomal membrane / lysosomal function: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| LAMP1 | participates_in | gene | 0.41 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lysosomal Positioning Dynamics Modulation | 0.430 | neurodegeneration | Autophagy-lysosome pathway convergence a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232] | Bayati A, McPherson PS | J Biol Chem | 2024 | 1 |
| Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818] | Zhang J, Zeng W, Han Y, Lee WR, Liou J, | Mol Cell | 2023 | 1 |
| Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279] | Saffire H Krance, Che-Yuan Wu, Alison C | Journal of Alzheimer's disease | 2022 | 1 |
| Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641] | Zhang X, Wei M, Fan J, Yan W, Zha X, Son | Autophagy | 2021 | 1 |
| Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206] | Eskelinen EL | Mol Aspects Med | 2006 | 1 |
| Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364] | Bizikova P, Matsumoto C, Ogino S, Tsukui | Vet Dermatol | 2026 | 0 |
| Measuring lysosome damage and lysophagy in vivo. [PMID:41485143] | Wu Z, Zhan H, Huang Z, Wang C, Li B et a | Autophagy | 2026 | 0 |
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675] | Luo J, Shi Y, Jiang X, Zhang B, Chen Y e | Int J Biol Macromol | 2026 | 0 |
| Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452] | Shi Y, Zhang N, Sun H, Wang Y, Zhao D et | Muscle Nerve | 2026 | 0 |
| Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components [PMID:37257946] | Idera A, Sharkey LM, Kurauchi Y, Kadoyam | Journal of pharmacological sci | 2023 | 0 |
| Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila. [PMID:35266854] | Chaudhry N, Sica M, Surabhi S, Hernandez | Autophagy | 2022 | 0 |
| Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. [PMID:34102054] | Chin MY, Patwardhan AR, Ang KH, Wang AL, | ACS sensors | 2021 | 0 |
| ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome-lysos [PMID:30538141] | Wang R, Tan J, Chen T, Han H, Tian R, Ta | The Journal of cell biology | 2019 | 0 |
| CD107a Degranulation Assay to Evaluate Immune Cell Antitumor Activity. [PMID:30465198] | Lorenzo-Herrero S, Sordo-Bahamonde C, Go | Methods in molecular biology ( | 2019 | 0 |
| Circumventing kinetics in biogeochemical modeling. [PMID:31097587] | ["Louca S", "Scranton M", "Taylor G", "A | Proceedings of the National Ac | 2019 | 0 |
| Revisiting LAMP1 as a marker for degradative autophagy-lysosomal organelles in t [PMID:29940787] | Cheng XT, Xie YX, Zhou B, Huang N, Farfe | Autophagy | 2018 | 0 |
| NUP98 is rearranged in 3.8% of pediatric AML forming a clinical and molecular ho [PMID:27694926] | ["Struski S", "Lagarde S", "Bories P", " | Leukemia | 2017 | 0 |
| Comprehensive Analysis of Hypermutation in Human Cancer. [PMID:29056344] | ["Campbell B", "Light N", "Fabrizio D", | Cell | 2017 | 0 |
| A model of synaptic vesicle-pool depletion and replenishment can account for the [PMID:25378173] | ["Peterson A", "Irvine D", "Heil P"] | The Journal of neuroscience : | 2014 | 0 |